Potassium Carbonate → HCID 68813959, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(1,3-dimethyl-2-phenyl-1H-indol-4-yl)-phenol (0.300 g, 0.957 mmol) was reacted with K2CO3 (0.159 g, 1.148 mmol) and bromoacetonitrile (0.134 g, 1.148 mmol) in acetone (5 ml) to give the product (0.311 g, 0.882 mmol, 92%) as a viscous oil. 1H NMR (DMSO-d6) δ 1.66 (s, 3H), 3.55 (s, 3H), 5.17 (s, 2H), 6.82 (dd, J=0.9, 7.2 Hz, 1H), 7.08 (d, J=8.9 Hz, 2H), 7.16 (t, J=7.2 Hz, 1H), 7.34-7.43 (m, 6H), 7.48 (t, J=7.0 Hz, 2H); [ESI(+)], m/z 353 (M+H)+.

Provenance & Evidence