Dichloromethane → HCID 68813801, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 3 of example 3. Thus, 5-bromo-1-methyl-3-pentyl-2-phenyl-1H-indole (1.105 g, 3.101 mmol) was reacted with aqueous 2M K2CO3 (3.1 ml), 4-methoxyphenylboronic acid (0.660 g, 4.341 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (1:1) (0.076 g, 0.093 mmol) in dioxane (31 ml) to give the product (0.512 g, 1.335 mmol, 43%) as an oily solid. 1H NMR (DMSO-d6) δ 0.76 (t, J=6.9 Hz, 3H), 1.15-1.23 (m, 4H), 1.52-1.56 (m, 2H), 2.66 (t, J=7.5 Hz, 2H), 3.56 (s, 3H), 3.79 (s, 3H), 7.02 (d, J=8.7 Hz, 2H), 7.41-7.46 (m, 3H), 7.47-7.49 (m, 2H), 7.53-7.56 (m, 2H), 7.61 (d, J=8.6 Hz, 2H), 7.72 (d, J=1.5 Hz, 1H); [ESI(+)], m/z 384 (M+H)+.

Provenance & Evidence