3,5-Dichloro-2-fluoropyridine → HCID 66837880, compound

HRID 73110Notes

Reaction equation

HRID 73110 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH:10]1([N:13]2[C:21]3[C:16](=[CH:17][C:18]([CH2:22][NH:23][S:24]([C:27]4[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=4)(=[O:26])=[O:25])=[CH:19][CH:20]=3)[CH:15]=[N:14]2)[CH2:12][CH2:11]1>>[CH:10]1([N:13]2[C:21]3[C:16](=[CH:17][C:18]([CH2:22][N:23]([C:3]4[C:2]([Cl:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=4)[S:24]([C:27]4[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=4)(=[O:26])=[O:25])=[CH:19][CH:20]=3)[CH:15]=[N:14]2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 27832563,5-Dichloro-2-fluoropyridineHCID 66837808methyl 4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

Product 1

HCID 66837880HCID 66837880, compound

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and methyl 4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-5 of Example 28).

Sources & evidence

ORD record
ord-08389ca55bed430ba55d13d9e7271c72
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

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