Potassium Carbonate → HCID 68814276, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 1 of example 4. Thus, 4-(1-methyl-3-pentyl-2-phenyl-1H-indol-5-yl)-phenol (0.180 g, 0.491 mmol) was reacted with K2CO3 (0.088 g, 0.639 mmol) and methyl bromoacetate (0.098 g, 0.639 mmol) in acetone (5 ml) to give the product (0.184 g, 0.417 mmol, 85%) as a viscous oil. 1H NMR (DMSO-d6) δ 0.76 (t, J=7.2 Hz, 3H), 1.15-1.22 (m, 4H), 1.51-1.56 (m, 2H), 2.65 (t, J=7.3 Hz, 2H), 3.56 (s, 3H), 3.71 (s, 3H), 4.83 (s, 2H), 7.01 (d, J=8.6 Hz, 2H), 7.41-7.45 (m, 3H), 7.47-7.50 (m, 2H), 7.54 (t, J=7.2 Hz, 2H), 7.61 (d, J=8.6 Hz, 2H), 7.73 (s, 1H); [ESI(+)], m/z 442 (M+H)+.

Provenance & Evidence