Benzyl Bromide → HCID 68814191, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 2 of example 3. Thus, 3-benzyl-5-bromo-2-phenyl-1H-indole (1.811 g, 5 mmol) was reacted with k-t-butoxide (0.589 g, 5.25 mmol) and benzyl bromide (0.901 g, 5.25 mmol) in DMF (20 ml) to give the product (1.932 g, 4.271 mmol, 85%) as a white solid, mp 155-157° C. 1H NMR (DMSO-d6) δ 3.99 (s, 2H), 5.32 (s, 2H), 6.82 (d, J=7.2 Hz, 2H), 7.07 (d, J=7.3 Hz, 2H), 7.09-7.23 (m, 7H), 7.34-7.39 (m, 3H), 7.43-7.49 (m, 3H), 7.53 (d, J=1.8 Hz, 1H); [ESI(+)], m/z 453/455 (M+H)+.

Provenance & Evidence