Potassium Carbonate → HCID 68814804, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 1 of example 4. Thus, 4-(1,3-dibenzyl-2-phenyl-1H-indol-5-yl)-phenol (0.541 g, 1.163 mmol) was reacted with K2CO3 (0.225 g, 1.628 mmol) and methyl bromoacetate (0.249 g, 1.628 mmol) in acetone (10 ml) to give the product (0.525 g, 0.976 mmol, 84%) as a solid. 1H NMR (DMSO-d6) δ 3.66 (s, 3H), 4.03 (s, 2H), 4.77 (s, 2H), 5.30 (s, 2H), 6.84 (d, J=6.8 Hz, 2H), 6.93 (d, J=8.8 Hz, 2H), 7.04-7.20 (m, 8H), 7.30 (dd, J=1.7, 8.5 Hz, 1H), 7.35-7.47 (m, 8H), 7.54 (d, J=1.2 Hz, 1H); [ESI(+)], m/z 538 (M+H)+.

Provenance & Evidence