Methyl iodide → HCID 68815678, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 2 of example 3. Thus, 3-benzyl-5-bromo-2-phenyl-1H-indole (1.811 g, 5 mmol) was reacted with k-t-butoxide (0.589 g, 5.25 mmol) and methyl iodide (0.745 g, 5.25 mmol) in DMF (20 ml) to give the product (1.537 g, 4.085 mmol, 82%) as a white solid, mp 141-145° C. 1H DMSO-d6) δ 3.56 (s, 3H), 3.93 (s, 2H), 7.02 (d, J=6.8 Hz, 2H), 7.07 (t, J=7.3 Hz, 1H), 7.15 (t, J=7.2 Hz, 2H), 7.23 (dd, J=2.0, 8.7 Hz, 1H), 7.40-7.52 (m, 7H); [ESI(+)], m/z 377/379 (M+H)+.

Provenance & Evidence