Dichloromethane → HCID 68814892, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 3 of example 3. Thus, 3-benzyl-5-bromo-1-methyl-2-phenyl-1H-indole (1.525 g, 4.053 mmol) was reacted with aqueous 2M K2CO3 (4.1 ml), 4-methoxyphenylboronic acid (0.862 g, 5.674 mmol) [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (1:1) (0.099 g, 0.122 mmol) in dioxane (41 ml) to give the product (0.766 g, 1.898 mmol, 47%) as an off-white solid, mp 122-125° C. 1H NMR (DMSO-d6) δ 3.62 (s, 3H), 3.77 (s, 3H), 4.04 (s, 2H), 6.98 (d, J=8.6 Hz, 2H), 7.07-7.11 (m, 3H), 7.18 (t, J=7.8 Hz, 2H), 7.42 (dd, J=1.5, 8.6 Hz, 1H), 7.45-7.55 (m, 9H); [ESI(+)], m/z 405 (M+H)+.

Provenance & Evidence