Potassium Carbonate → HCID 68814796, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(3-benzyl-1-methyl-2-phenyl-1H-indol-5-yl)-phenol (0.140 g, 0.359 mmol) was reacted with K2CO3 (0.065 g, 0.467 mmol) and bromoacetonitrile (0.056 g, 0.467 mmol) in acetone (5 ml) to give the product (0.141 g, 0.329 mmol, 92%) as a glass-like solid. 1H NMR (DMSO-d6) δ 3.62 (s, 3H), 4.04 (s, 2H), 5.18 (s, 2H), 7.07-7.13 (m, 5H), 7.18 (t, J=7.5 Hz, 2H), 7.44-7.49 (m, 4H), 7.52-7.55 (m, 3H), 7.57-7.60 (m, 3H); [ESI(+)], m/z 429 (M+H)+.

Provenance & Evidence