HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 731131Generated: October 31, 2026
7-methyl-2-benzofuran-1(3H)-one → 2-{3-[2-(4-Fluorophenyl)oxazol-4-ylmethoxy]phenoxymethyl}-6-methylbenzoic acid
https://huagongshe.com/reaction/731131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 7-methyl-2-benzofuran-1(3H)-one | HCID 638757 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-[2-(4-Fluorophenyl)oxazol-4-ylmethoxy]phenol | HCID 69050169 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-{3-[2-(4-Fluorophenyl)oxazol-4-ylmethoxy]phenoxymethyl}-6-methylbenzoic acid | HCID 11407847 | — |
Reaction Steps
1 g (6.8 mmol) of 7-methylphthalide and 2 g (7.0 mmol) of 3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]phenol are dissolved in NMP. 3.9 ml of methanolic sodium methoxide (30% strength) are added, the methanol is distilled off, and the mixture is heated to 130° C. No formation of 2-{3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]phenoxymethyl}-6-methyl-benzoic acid is observed. The 3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]phenol decomposes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07582794B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-ea1319b7318c4eec9b820149a77944ff |
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| Source note | uspto-grants-2009_09 |
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