3,5-Dichloro-2-fluoropyridine → HCID 66837839, compound

HRID 73114Notes

Reaction equation

HRID 73114 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[S:22](=[O:38])(=[O:37])[NH:23][CH2:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[N:30]([CH:34]1[CH2:36][CH2:35]1)[N:29]=[CH:28]2)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[Cl:10][C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[S:22](=[O:37])(=[O:38])[N:23]([CH2:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[N:30]([CH:34]1[CH2:36][CH2:35]1)[N:29]=[CH:28]2)[C:3]1[C:2]([Cl:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=1)[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

3

Reactant 2

HCID 27832563,5-Dichloro-2-fluoropyridineHCID 66837877HCID 66837877, compound

Product 1

HCID 66837839HCID 66837839, compound

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and ethyl 3-chloro-4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-1 of Example 31).

Sources & evidence

ORD record
ord-1f8b9f2b3bdf4e489f78bbf4b25dc270
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

Loading…