HRID73115

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID112234

2,3-Dichloro-5-(trifluoromethyl)pyridine

C6H2Cl2F3N

结构：COC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(cnn3C3CC3)c2)c(C)c1

HCID66837887

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(cnn3C3CC3)c2)c2ncc(C(F)(F)F)cc2Cl)c(C)c1

HCID66837909

未命名化合物

PROCEDURE

实验过程

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and methyl 4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)-3-methylbenzoate (step-2 of Example 33).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-52a7d8504edf4fc7884c4d2a85c00605
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08829026B2
来源说明: uspto-grants-2014_09

反应 SMILES

Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[CH:13]1([N:16]2[C:24]3[C:19](=[CH:20][C:21]([CH2:25][NH:26][S:27]([C:30]4[CH:39]=[CH:38][C:33]([C:34]([O:36][CH3:37])=[O:35])=[CH:32][C:31]=4[CH3:40])(=[O:29])=[O:28])=[CH:22][CH:23]=3)[CH:18]=[N:17]2)[CH2:15][CH2:14]1>>[Cl:8][C:7]1[C:2]([N:26]([CH2:25][C:21]2[CH:20]=[C:19]3[C:24](=[CH:23][CH:22]=2)[N:16]([CH:13]2[CH2:15][CH2:14]2)[N:17]=[CH:18]3)[S:27]([C:30]2[CH:39]=[CH:38][C:33]([C:34]([O:36][CH3:37])=[O:35])=[CH:32][C:31]=2[CH3:40])(=[O:29])=[O:28])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1