3,5-Dichloro-2-fluoropyridine → Methyl 4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)-N-(3,5-dichloropyridin-2-yl)sulfamoyl)-3-methylbenzoate

HRID 73116Notes

Reaction equation

HRID 73116 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH:10]1([N:13]2[C:21]3[C:16](=[CH:17][C:18]([CH2:22][NH:23][S:24]([C:27]4[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][C:28]=4[CH3:37])(=[O:26])=[O:25])=[CH:19][CH:20]=3)[CH:15]=[N:14]2)[CH2:12][CH2:11]1>>[CH:10]1([N:13]2[C:21]3[C:16](=[CH:17][C:18]([CH2:22][N:23]([C:3]4[C:2]([Cl:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=4)[S:24]([C:27]4[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][C:28]=4[CH3:37])(=[O:26])=[O:25])=[CH:19][CH:20]=3)[CH:15]=[N:14]2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 27832563,5-Dichloro-2-fluoropyridineHCID 66837887HCID 66837887, compound

Product 1

HCID 66837847Methyl 4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)-N-(3,5-dichloropyridin-2-yl)sulfamoyl)-3-methylbenzoate

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and methyl 4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)-3-methylbenzoate (step-2 of Example 33).

Sources & evidence

ORD record
ord-3f373c9a8dab4dd1a1d927ca12c41fcb
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

Loading…