Cesium fluoride → HCID 86611518, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.3 (74 mg, 0.18 mmol), 4-(trifluoromethyl)phenylboronic acid (45.8 mg, 0.22 mmol) and CsF (56 mg, 0.37 mmol) in 1,2-dimethoxyethane (2 mL), was degassed with N2 for 3 minutes. Pd(PPh3)4 (21 mg, 0.018 mmol) was added, and the resulting mixture was heated at 95° C. for 8 hours. After cooling, the reaction mixture was quenched with water and extracted with EtOAc providing 1.4 (20 mg), which was directly hydrolyzed in the next step.

Provenance & Evidence