5-Bromo-1-chloro-2,3-dihydro-1H-indene → HCID 57835828, compound

HRID 731182Notes

Reaction equation

HRID 731182 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7](Cl)[CH2:6][CH2:5]2.[OH:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([N:25]2[CH:29]=[CH:28][CH:27]=[N:26]2)[CH2:20][C:21]([O:23][CH3:24])=[O:22])=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([O:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([N:25]3[CH:29]=[CH:28][CH:27]=[N:26]3)[CH2:20][C:21]([O:23][CH3:24])=[O:22])=[CH:15][CH:14]=1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 223495155-Bromo-1-chloro-2,3-dihydro-1H-indeneHCID 57835822methyl 3-(4-hydroxyphenyl)-3-(1H-pyrazol-1-yl)propanoate

Product 1

HCID 57835828HCID 57835828, compoundYield 30%

Conditions

Temperature
40 °C

Procedure

A mixture of 47.3 (0.16 mmol) and methyl 3-(4-hydroxyphenyl)-3-(1H-pyrazol-1-yl)propanoate 47.4 (obtained by the procedure of Example 58 set forth in US 2006/0004012 which is hereby incorporated by reference) (0.11 mmol) was stirred at 40° C. for 1 hour. After work up and chromatography, 47.5 was obtained in 30% yield. MS ESI (pos.) M/E: 441, 443 (M+H).

Workup

  1. customobtained by the procedure of Example 58
  2. customAfter work up and chromatography, 47.5 was obtained in 30% yield

Sources & evidence

ORD record
ord-80a5133d264843739d94a8eaddcb29cc
Source dataset
uspto-grants-2009_09
Patent number
US07582803B2

Reaction notes

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