Cesium fluoride → HCID 57835769, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 59.2 (30 mg, 0.073 mmol), 3-ethoxyphenylboronic acid (14.5 mg, 0.087 mmol) and CsF (55 mg, 0.36 mmol) in 1,2-dimethoxyethane (2 mL) was degassed with N2 for 3 minutes. Pd(PPh3)4 (20 mg, 0.017 mmol) was added, and the resulting mixture was heated to 95° C. for 8 hours. After cooling, the reaction mixture was quenched with water and extracted with EtOAc to obtain the ester 59.3, which was directly hydrolyzed in next step.

Provenance & Evidence