Hydrochloric Acid → HCID 57835870, compound

Participants

Reaction Steps

A solution of 59.3 in THF/MeOH (1:1, 2 mL), was treated with 2N NaOH aqueous solution (1 mL) and stirred for overnight at room temperature. The reaction mixture was acidified with aqueous 4N HCl and extracted with EtOAc to obtain 59, which was purified by preparative HPLC, eluting with 5˜95% ACN in water containing 0.1% TFA. MS ESI (neg.) m/e: 439.1 (M−H). 1HNMR (MeOD-d4) δ 7.65 (br, 1H), 7.48 (s, 1H), 7.38 (d, 1H, J=7.02 Hz), 7.32 (t, 1H, J=7.12 Hz), 7.18 (d, 1H, J=6.57 Hz), 7.14 (s, 1H), 7.06 (m, 2H), 6.99-6.86 (m, 2H), 6.78 (m, 1H), 4.79 (m, 1H), 4.12 (q, 2H, J=6.50 Hz), 3.86 (m, 1H), 3.15-3.01 (m, 2H), 2.54-2.42 (m, 2H), 2.03 (m, 1H), 1.74 (ss, 3H), 1.42 (t, 3H, J=6.74 Hz).

Provenance & Evidence