3,5-Dichloro-2-fluoropyridine → Ethyl 3-chloro-4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl) methyl)sulfamoyl)benzoate

HRID 73120Notes

Reaction equation

HRID 73120 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[S:22](=[O:36])(=[O:35])[NH:23][CH2:24][C:25]1[CH:26]=[C:27]2[CH:33]=[CH:32][N:31]([CH3:34])[C:28]2=[N:29][CH:30]=1)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[Cl:10][C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[S:22](=[O:35])(=[O:36])[N:23]([C:3]1[C:2]([Cl:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=1)[CH2:24][C:25]1[CH:26]=[C:27]2[CH:33]=[CH:32][N:31]([CH3:34])[C:28]2=[N:29][CH:30]=1)[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

3

Reactant 2

HCID 27832563,5-Dichloro-2-fluoropyridineHCID 66837935HCID 66837935, compound

Product 1

HCID 66837858Ethyl 3-chloro-4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl) methyl)sulfamoyl)benzoate

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and ethyl 3-chloro-4-(N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate (step-2 of Example 35).

Sources & evidence

ORD record
ord-bf75cf9f13bf4edab9005daa52ffd29b
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

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