Potassium Phosphate, Tribasic → HCID 86611519, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	Cyclopropylboronic acid	HCID 2760897	—
Reactant	2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl	HCID 11269872	—
Reactant	HCID 57835754	HCID 57835754	—
Catalyst	palladium(II) acetate	HCID 167845	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 86611519	HCID 86611519	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

The mixture of compound 91 (166 mg, 0.3 mmol), cyclopropyl boronic acid (129 mg, 1.5 mmol), K3PO4 (212 mg, 1 mmol), Pd(OAc)2 (26 mg, 0.12 mmol), Sphos (100 mg, 0.24 mmol) and dioxane (3 mL) was purged with nitrogen, and then heated at 100° C. overnight. The reaction mixture was directly purified by CombiFlash. The compound 92.1 was generated as a colorless oil. LC-MS ESI (pos.) M/E: 515 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07582803B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-1ceea29615954724a4d9f997bf7df0b0
Source note	uspto-grants-2009_09