Benzylamine → 2,5-Diaminobenzenesulfonamide

Participants

Reaction Steps

The 2-chloro-5-nitro-benzenesulfonamide intermediate (prepared as described in schemes 16 and 18) can be treated with a benzylic amine, such as benzylamine, to displace the chloro moiety. Hydrogenation under standard conditions can be used to remove the benzylic group and to reduce the nitro group at the same time to afford the desired 2,5-diamino-benzenesulfonamide intermediate.

Provenance & Evidence