2,3-Dichloro-5-(trifluoromethyl)pyridine → Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(quinolin-3-ylmethyl)sulfamoyl)benzoate

HRID 73124Notes

Reaction equation

HRID 73124 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]([CH2:23][NH:24][S:25]([C:28]2[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=2)(=[O:27])=[O:26])[CH:14]=1>>[Cl:8][C:7]1[C:2]([N:24]([CH2:23][C:15]2[CH:14]=[N:13][C:22]3[C:17]([CH:16]=2)=[CH:18][CH:19]=[CH:20][CH:21]=3)[S:25]([C:28]2[CH:29]=[CH:30][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:36][CH:37]=2)(=[O:26])=[O:27])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

Participants

3

Reactant 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 66837921HCID 66837921, compound

Product 1

HCID 66837894Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(quinolin-3-ylmethyl)sulfamoyl)benzoate

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and methyl 4-(N-(quinolin-3-ylmethyl)sulfamoyl)benzoate (step-1 of Example 38).

Sources & evidence

ORD record
ord-d4388f6945054f78926bfebf788fecbf
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

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