Acetyl chloride → N'-Allyl-N'-cyclobutyl-hydrazine hydrochloride

Participants

Reaction Conditions

Reaction Steps

Acetyl chloride (1.45 mL, 20.41 mmol) was added dropwise into methanol (10 mL) at 0° C. The resulting mixture was stirred at 25° C. for 30 min. N′-allyl-N′-cyclobutyl-hydrazinecarboxylic acid tert-butyl ester (0.40 g, 1.77 mmol) was added in one portion. The reaction was stirred at 25° C. for 18 h. The mixture was concentrated in vacuo and used directly in the next step.

Provenance & Evidence