1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-1-(4-methyl-cyclohexyl)-3-(5-methyl-thiazol-2-yl)-urea → 1-(4-Methyl-cyclohexyl)-3-(5-methyl-thiazol-2-yl)-1-(4-oxo-cyclohexyl)-urea

Participants

Reaction Steps

A solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1-(4-methyl-cyclohexyl)-3-(5-methyl-thiazol-2-yl)-urea (100 mg, 0.25 mmol) in 80% aqueous acetic acid (1.15 mL) was heated at 60° C. for 3½ h. The reaction mixture was evaporated to dryness in vacuo to give a golden oil. The crude product was purified by HPLC to give the title compound.

Provenance & Evidence