Ethyl 2-bromopropionate → HCID 57688365, compound

HRID 731412Notes

Reaction equation

HRID 731412 reaction equation
[CH:1]1([N:7]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:8](=[O:22])[NH:9][C:10]2[S:11][C:12]([S:15][C:16](C)([CH3:20])[C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.BrC(C)C(OCC)=O>>[CH:23]1([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8](=[O:22])[NH:9][C:10]2[S:11][C:12]([S:15][CH:16]([CH3:20])[C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 57688193HCID 57688193, compound

Product 1

HCID 57688365HCID 57688365, compound

Procedure

The title compound was prepared in a similar manner to 2-[2-(3,3-dicyclohexyl-ureido)-thiazol-5-ylsulfanyl]-2-methyl-propionic acid using ethyl 2-bromoproprionate as the alkylating agent.

Sources & evidence

ORD record
ord-12bc0d88b2b8440ba7efbdb53d74e919
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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