Cyclohexanone → HCID 57688270, compound

HRID 731413Notes

Reaction equation

HRID 731413 reaction equation
[CH:1]1([N:6]([C@H:20]2[CH2:25][CH2:24][C@H:23](OC)[CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][N:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:28]1(N)CCC=CC1.C1(=O)CCCCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH:1]1([N:6]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][N:13]=2)[CH2:5][CH2:4][CH:3]=[CH:2][CH2:28]1

Participants

5

Reactant 4

HCID 7967CyclohexanoneHCID 13040867Cyclohex-3-en-1-amineHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178496618HCID 178496618, compound

Product 1

HCID 57688270HCID 57688270, compound

Procedure

Prepared in accordance with the procedure for the synthesis of {2-[3-cyclopentyl-3-(trans-4-methoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using cyclohex-3-enylamine, cyclohexanone and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester as starting material.

Sources & evidence

ORD record
ord-f9d5bedec06a4a489b7ba306efb05b6e
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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