HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → HCID 57688329, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | tert-Butyl 2-oxopiperidine-1-carboxylate | HCID 7577838 | — |
| Reactant | Ethyl 2-(2-aminothiazol-5-ylthio)acetate | HCID 21455623 | — |
| Reactant | HCID 86630188 | HCID 86630188 | — |
| Product | HCID 57688329 | HCID 57688329 | — |
Reaction Steps
{2-[3-Cyclohexyl-3-piperidin-4-yl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester was pre-pared in a similar manner to the synthesis of example 12 from N-Boc piperidone, cyclohexyl-amine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester, Boc deprotection, reaction with dimethylcarbamoyl chloride and hydrolysis of the ester moiety as described in general procedure (I) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582769B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-627c1e00e73646249f3f2b8700654ef9 |
| Source note | uspto-grants-2009_09 |