1-(2-Pyrimidinyl)piperazine → HCID 178473851, compound

HRID 731420Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([C@H:29]2[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21](=[O:28])[N:22]3[CH2:27]CC[CH2:24][CH2:23]3)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C([N:39]1[CH2:44][CH2:43][CH:42]([N:45]([C@H]2CC[C@H](C)CC2)[C:46](=O)[NH:47][C:48]2SC(SCC(O)=O)=CN=2)CC1)(=O)C.N1(C2N=CC=CN=2)CCNCC1>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([C@H:29]2[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21](=[O:28])[N:22]3[CH2:27][CH2:48][N:47]([C:46]4[N:45]=[CH:42][CH:43]=[CH:44][N:39]=4)[CH2:24][CH2:23]3)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 887471-(2-Pyrimidinyl)piperazine

HCID 178473850HCID 178473850, compound

HCID 178473853HCID 178473853, compound

Product 1

HCID 178473851HCID 178473851, compound

Procedure

Prepared in a similar manner to 1-(1-acetyl-piperidin-4-yl)-1-(trans-4-methyl-cyclohexyl)-3-[5-(2-oxo-2-piperidin-1-yl-ethylsulfanyl)-thiazol-2-yl]-urea using {2-[3-(1-acetyl-piperidin-4-yl)-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and 2-(piperazinyl)pyrimidine.

Sources & evidence

ORD record: ord-0216c7559bb046ccb6772c6dfdf83e70
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582769B2

Reaction notes

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