Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoate → HCID 178455809, compound

HRID 731428Notes

Reaction equation

HRID 731428 reaction equation
[CH:1]1([N:6]([C@H:20]2[CH2:25][CH2:24][C@H:23]([CH2:26][CH3:27])[CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14]CC(O)=O)=[CH:12][N:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C1(N[C@H]2CC[C@H](CC)CC2)CCCC1.C([O:44][C:45](=[O:55])[CH2:46][CH2:47]SC1SC(N)=NC=1)C>>[CH:1]1([N:6]([C@H:20]2[CH2:25][CH2:24][C@H:23]([CH2:26][CH3:27])[CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:47][CH2:46][C:45]([OH:55])=[O:44])=[CH:12][N:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178455796HCID 178455796, compoundHCID 178455810HCID 178455810, compound

Product 1

HCID 178455809HCID 178455809, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclopentyl-(trans-4-ethyl-cyclohexyl)-amine and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-ee1e2cc43b864feaba175a061c83d7b4
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

Loading…