Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoate → HCID 178448125, compound

HRID 731429Notes

Reaction equation

HRID 731429 reaction equation
[CH:1]1([N:6]([C@H:20]2[CH2:25][CH2:24][C@H:23]([CH2:26][CH3:27])[CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15]C(O)=O)=[CH:12][N:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:28]1(N[C@H]2CC[C@H](C(C)C)CC2)CCCC1.C([O:45][C:46](=[O:56])[CH2:47]CSC1SC(N)=NC=1)C>>[CH:1]1([N:6]([C@H:20]2[CH2:25][CH2:24][C@H:23]([CH:26]([CH3:28])[CH3:27])[CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][CH2:47][C:46]([OH:56])=[O:45])=[CH:12][N:13]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178448110HCID 178448110, compoundHCID 178455810HCID 178455810, compound

Product 1

HCID 178448125HCID 178448125, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclopentyl-(trans-4-isopropyl-cyclohexyl)-amine and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-69a2ce9e45684bc791d4fa87b5b43ded
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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