(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester → HCID 178467892, compound

HRID 731436Notes

Reaction equation

HRID 731436 reaction equation
[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24]([CH2:27][O:28][CH3:29])[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16]C(O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:30]1(N[C@H]2CC[C@H](COCC)CC2)CCCCC1.C([O:49][C:50](=[O:60])[CH:51](SC1SC(N)=NC=1)C)C>>[CH:1]1([N:7]([C@H:21]2[CH2:22][CH2:23][C@H:24]([CH2:27][O:28][CH2:29][CH3:30])[CH2:25][CH2:26]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][CH2:51][C:50]([OH:60])=[O:49])=[CH:13][N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178467886HCID 178467886, compoundHCID 178495639HCID 178495639, compound

Product 1

HCID 178467892HCID 178467892, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(trans-4-ethoxymethyl-cyclohexyl)-amine and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-cc5b149bfb744eb78831e59f0a6d432c
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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