4-tert-butyl-N-cyclopentylcyclohexan-1-amine → HCID 178445692, compound

HRID 731437Notes

Reaction equation

HRID 731437 reaction equation
C1(N([C@H]2CC[C@H](CC)CC2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16](O)=O)=[CH:12][N:13]=2)CCCC1.[C:28]([CH:32]1[CH2:37][CH2:36][CH:35]([NH:38][CH:39]2[CH2:43][CH2:42][CH2:41][CH2:40]2)[CH2:34][CH2:33]1)([CH3:31])([CH3:30])[CH3:29].C([O:46][C:47](=[O:57])CCSC1SC(N)=NC=1)C>>[C:28]([C@H:32]1[CH2:37][CH2:36][C@H:35]([N:38]([CH:39]2[CH2:43][CH2:42][CH2:41][CH2:40]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][CH2:16][C:47]([OH:57])=[O:46])=[CH:12][N:13]=2)[CH2:34][CH2:33]1)([CH3:31])([CH3:29])[CH3:30]

Participants

4

Reactant 3

HCID 285532804-tert-butyl-N-cyclopentylcyclohexan-1-amineHCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178455810HCID 178455810, compound

Product 1

HCID 178445692HCID 178445692, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via (4-tert-butyl-cyclohexyl)-cyclopentyl-amine and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-c5bf48b8c0254e048f9be947cee80a62
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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