4-tert-butyl-N-cyclopentylcyclohexan-1-amine → HCID 178460745, compound

HRID 731440Notes

Reaction equation

HRID 731440 reaction equation
C1(N([C@H]2CC[C@H](CC)CC2)C(=O)NC2SC(SC[C:16](O)=[O:17])=CN=2)CCCC1.[C:28]([CH:32]1[CH2:37][CH2:36][CH:35]([NH:38][CH:39]2[CH2:43][CH2:42][CH2:41][CH2:40]2)[CH2:34][CH2:33]1)([CH3:31])([CH3:30])[CH3:29].C([O:46][C:47](=[O:58])[C:48]([S:51][C:52]1[S:56][C:55]([NH2:57])=[N:54][CH:53]=1)([CH3:50])[CH3:49])C>>[C:28]([C@H:32]1[CH2:37][CH2:36][C@H:35]([N:38]([CH:39]2[CH2:43][CH2:42][CH2:41][CH2:40]2)[C:16](=[O:17])[NH:57][C:55]2[S:56][C:52]([S:51][C:48]([CH3:50])([CH3:49])[C:47]([OH:46])=[O:58])=[CH:53][N:54]=2)[CH2:34][CH2:33]1)([CH3:31])([CH3:29])[CH3:30]

Participants

4

Reactant 3

HCID 285532804-tert-butyl-N-cyclopentylcyclohexan-1-amineHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178455810HCID 178455810, compound

Product 1

HCID 178460745HCID 178460745, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (Example 38) via (4-tert-butyl-cyclohexyl)-cyclopentyl-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-bb155d6317b3409b9f1347afcbcfb17e
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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