4-tert-butyl-N-cyclohexylcyclohexan-1-amine → HCID 178460746, compound

HRID 731441Notes

Reaction equation

HRID 731441 reaction equation
C1(N([C@H]2CC[C@H](CC)CC2)C(=O)NC2SC(SC[C:16](O)=[O:17])=CN=2)CCCC1.[C:28]([CH:32]1[CH2:37][CH2:36][CH:35]([NH:38][CH:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)[CH2:34][CH2:33]1)([CH3:31])([CH3:30])[CH3:29].C([O:47][C:48](=[O:59])[C:49]([S:52][C:53]1[S:57][C:56]([NH2:58])=[N:55][CH:54]=1)([CH3:51])[CH3:50])C>>[C:28]([C@H:32]1[CH2:37][CH2:36][C@H:35]([N:38]([CH:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)[C:16](=[O:17])[NH:58][C:56]2[S:57][C:53]([S:52][C:49]([CH3:51])([CH3:50])[C:48]([OH:47])=[O:59])=[CH:54][N:55]=2)[CH2:34][CH2:33]1)([CH3:31])([CH3:29])[CH3:30]

Participants

4

Reactant 3

HCID 131843274-tert-butyl-N-cyclohexylcyclohexan-1-amineHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178455810HCID 178455810, compound

Product 1

HCID 178460746HCID 178460746, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (Example 38) via (4-tert-butyl-cyclohexyl)-cyclohexyl-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-3bc3fc5bd0194e538c84db66bb47e596
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

Loading…