HCID 67483465, compound → HCID 178495636, compound

HRID 731442Notes

Reaction equation

HRID 731442 reaction equation
[CH:1]1([N:7]([C@H:21]2C[CH2:25][C@H:24](COC)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15]CC(O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(N[C@H]2C[C@H]([CH2:42][O:43][CH3:44])CC2)CCCCC1.C([O:47][C:48](=[O:58])[CH:49](SC1SC(N)=NC=1)[CH3:50])C>>[CH:21]1([N:7]([C@H:1]2[CH2:2][CH2:3][C@H:4]([CH2:42][O:43][CH3:44])[CH2:5][CH2:6]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:50][CH2:49][C:48]([OH:47])=[O:58])=[CH:13][N:14]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 67483465HCID 67483465, compoundHCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178495639HCID 178495639, compound

Product 1

HCID 178495636HCID 178495636, compound

Procedure

Prepared in an similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(trans-4-methoxymethyl-cyclopentyl)-amine and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-d4c03381fb3e4595b35e1092aae2d5bf
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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