Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178467891, compound

HRID 731446Notes

Reaction equation

HRID 731446 reaction equation
C1(N([C@H]2CC[C@H](COC)CC2)C(=O)NC2SC(SC[C:17](O)=[O:18])=CN=2)CCCCC1.[CH:30]1([NH:37][C@H:38]2[CH2:44][CH2:43]C[C@H:41]([CH2:45][O:46][CH2:47][CH3:48])[CH2:40][CH2:39]2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C([O:51][C:52](=[O:63])[C:53]([S:56][C:57]1[S:61][C:60]([NH2:62])=[N:59][CH:58]=1)([CH3:55])[CH3:54])C>>[CH:30]1([N:37]([C@H:38]2[CH2:39][CH2:40][C@H:41]([CH2:45][O:46][CH2:47][CH3:48])[CH2:43][CH2:44]2)[C:17](=[O:18])[NH:62][C:60]2[S:61][C:57]([S:56][C:53]([CH3:55])([CH3:54])[C:52]([OH:51])=[O:63])=[CH:58][N:59]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1

Participants

4

Reactant 3

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 67483638Cycloheptyl-(trans-4-ethoxymethyl-cycloheptyl)amineHCID 178495639HCID 178495639, compound

Product 1

HCID 178467891HCID 178467891, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cycloheptyl-(trans-4-ethoxymethyl-cycloheptyl)-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-bcd15ac264d249d2bb61e5dfbcc4b82a
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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