Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178495635, compound

HRID 731447Notes

Reaction equation

HRID 731447 reaction equation
C1(N([C@H]2CC[C@H](COC)CC2)C(=O)NC2SC(SC[C:17](O)=[O:18])=CN=2)CCCCC1.[CH:30]1([NH:37][C@H:38]2[CH2:44][CH2:43]C[C@H:41]([CH2:45][O:46][CH3:47])[CH2:40][CH2:39]2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C([O:50][C:51](=[O:62])[C:52]([S:55][C:56]1[S:60][C:59]([NH2:61])=[N:58][CH:57]=1)([CH3:54])[CH3:53])C>>[CH:30]1([N:37]([C@H:38]2[CH2:39][CH2:40][C@H:41]([CH2:45][O:46][CH3:47])[CH2:43][CH2:44]2)[C:17](=[O:18])[NH:61][C:59]2[S:60][C:56]([S:55][C:52]([CH3:54])([CH3:53])[C:51]([OH:50])=[O:62])=[CH:57][N:58]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1

Participants

4

Reactant 3

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 67483608HCID 67483608, compoundHCID 178495639HCID 178495639, compound

Product 1

HCID 178495635HCID 178495635, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cycloheptyl-(trans-4-methoxymethyl-cycloheptyl)-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-ed055a29a7104e1ea4963cb01e14b535
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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