Dicyclohexylamine → 3-[2-(3,3-Dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-propionic acid

HRID 731449Notes

Reaction equation

HRID 731449 reaction equation
[CH:1]1([N:7]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([NH:18]CC(O)=O)(=[O:17])=[O:16])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(NC2CCCCC2)CCCCC1.C([O:45][C:46](=[O:59])[CH2:47][CH2:48]NS(C1SC(N)=NC=1)(=O)=O)C>>[CH:1]1([N:7]([CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([NH:18][CH2:48][CH2:47][C:46]([OH:59])=[O:45])(=[O:17])=[O:16])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 7582DicyclohexylamineHCID 57688273N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycineHCID 866298803-(2-Amino-thiazole-5-sulfonylamino)propionic acid ethyl ester

Product 1

HCID 576882893-[2-(3,3-Dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-propionic acid

Procedure

Prepared in a similar manner to [2-(3,3-dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-acetic acid via dicyclohexylamine and 3-(2-amino-thiazole-5-sulfonylamino)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-07e27589b1224bc2ac399395e1160455
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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