N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycine → HCID 178461395, compound

HRID 731450Notes

Reaction equation

HRID 731450 reaction equation
[CH:1]1([N:7]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([NH:18]CC(O)=O)(=[O:17])=[O:16])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:30]1(N[C@H]2CC[C@H](C)CC2)CCCCC1.C([O:46][C:47](=[O:60])[CH2:48][CH2:49]NS(C1SC(N)=NC=1)(=O)=O)C>>[CH:24]1([N:7]([C@H:1]2[CH2:6][CH2:5][C@H:4]([CH3:30])[CH2:3][CH2:2]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([NH:18][CH2:49][CH2:48][C:47]([OH:60])=[O:46])(=[O:17])=[O:16])=[CH:13][N:14]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 57688273N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycineHCID 866298803-(2-Amino-thiazole-5-sulfonylamino)propionic acid ethyl esterHCID 178461295HCID 178461295, compound

Product 1

HCID 178461395HCID 178461395, compound

Procedure

Prepared in a similar manner to [2-(3,3-dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-acetic acid via cyclohexyl-(trans-4-methyl-cyclohexyl)-amine and 3-(2-amino-thiazole-5-sulfonylamino)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-924af65dc84e44f29464b957b9c42a32
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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