Dicyclohexylamine → {[2-(3,3-Dicyclohexyl-ureido)-thiazole-5-sulfonyl]-methyl-amino}-acetic acid

HRID 731451Notes

Reaction equation

HRID 731451 reaction equation
[CH:1]1([N:7]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([NH:18][CH2:19][C:20]([OH:22])=[O:21])(=[O:17])=[O:16])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:30]1(NC2CCCCC2)CCCCC1.COC(=O)CN(S(C1SC(N)=NC=1)(=O)=O)C>>[CH:24]1([N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([N:18]([CH2:19][C:20]([OH:22])=[O:21])[CH3:30])(=[O:16])=[O:17])=[CH:13][N:14]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 7582DicyclohexylamineHCID 57688273N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycineHCID 86630193[(2-Amino-thiazole-5-sulfonyl)-methyl-amino]-acetic acid methyl ester

Product 1

HCID 57688247{[2-(3,3-Dicyclohexyl-ureido)-thiazole-5-sulfonyl]-methyl-amino}-acetic acid

Procedure

Prepared in a similar manner to [2-(3,3-dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-acetic acid via dicyclohexylamine and [(2-amino-thiazole-5-sulfonyl)-methyl-amino]-acetic acid methyl ester to give the title compound.

Sources & evidence

ORD record
ord-3034be2db4a6423eadc6f51e09c5d5ee
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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