N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycine → HCID 178484758, compound

HRID 731452Notes

Reaction equation

HRID 731452 reaction equation
C1(N(C2CCCCC2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([NH:18][CH2:19][C:20]([OH:22])=[O:21])(=[O:17])=[O:16])=[CH:13][N:14]=2)CCCCC1.[CH:30]1([NH:36][C@H:37]2[CH2:42][CH2:41][C@H:40]([CH3:43])[CH2:39][CH2:38]2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.[CH3:44]OC(=O)CN(S(C1SC(N)=NC=1)(=O)=O)C>>[CH:30]1([N:36]([C@H:37]2[CH2:38][CH2:39][C@H:40]([CH3:43])[CH2:41][CH2:42]2)[C:8](=[O:23])[NH:9][C:10]2[S:11][C:12]([S:15]([N:18]([CH2:19][C:20]([OH:22])=[O:21])[CH3:44])(=[O:17])=[O:16])=[CH:13][N:14]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

Participants

4

Reactant 3

HCID 57688273N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycineHCID 86630193[(2-Amino-thiazole-5-sulfonyl)-methyl-amino]-acetic acid methyl esterHCID 178461295HCID 178461295, compound

Product 1

HCID 178484758HCID 178484758, compound

Procedure

Prepared in a similar manner to [2-(3,3-dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-acetic acid via cyclohexyl-(trans-4-methyl-cyclohexyl)-amine and [(2-amino-thiazole-5-sulfonyl)-methyl-amino]-acetic acid methyl ester to give the title compound.

Sources & evidence

ORD record
ord-a9ad8ee91e734a7dbdf06aabbb19b40d
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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