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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 731453Generated: October 30, 2026

Dicyclohexylamine → (S)-1-[2-(3,3-Dicyclohexyl-ureido)-thiazole-5-sulfonyl]-pyrrolidine-2-carboxylic acid

https://huagongshe.com/reaction/731453

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylamineHCID 7582—
ReactantN-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycineHCID 57688273—
Reactant(S)-1-(2-aminothiazole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl esterHCID 86629877—
Product(S)-1-[2-(3,3-Dicyclohexyl-ureido)-thiazole-5-sulfonyl]-pyrrolidine-2-carboxylic acidHCID 57688281—

Reaction Steps

Prepared in a similar manner to [2-(3,3-dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-acetic acid via dicyclohexylamine and (S)-1-(2-amino-thiazole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07582769B2
Source datasetuspto-grants-2009_09
ORD IDord-546559ae712d45f99ae3f1a759b5a2da
Source noteuspto-grants-2009_09