(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester → HCID 178450581, compound

HRID 731456Notes

Reaction equation

HRID 731456 reaction equation
[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24]([O:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15]CC(O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O:34][C:35](=[O:45])[CH:36](SC1SC(N)=NC=1)[CH3:37])C>>[CH:1]1([N:7]([C@H:21]2[CH2:22][CH2:23][C@H:24]([O:27][CH2:28][CH:29]([CH3:30])[CH3:31])[CH2:25][CH2:26]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:37][CH2:36][C:35]([OH:45])=[O:34])=[CH:13][N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178450582HCID 178450582, compound

Product 1

HCID 178450581HCID 178450581, compound

Procedure

Prepared as described for the synthesis of {2-[3-cyclohexyl-3-(trans-4-isobutoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-acetic acid ethyl ester in the coupling step.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0136ee5e0aa7417b86b5e3487138ecce
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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