Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178467890, compound

HRID 731457Notes

Reaction equation

HRID 731457 reaction equation
C1(N([C@H]2CC[C@H](COC)CC2)C(=O)NC2SC(SC[C:17](O)=[O:18])=CN=2)CCCCC1.[CH:30]1([NH:36][C@H:37]2[CH2:42][CH2:41][C@H:40]([CH2:43][O:44][CH2:45][CH3:46])[CH2:39][CH2:38]2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C([O:49][C:50](=[O:61])[C:51]([S:54][C:55]1[S:59][C:58]([NH2:60])=[N:57][CH:56]=1)([CH3:53])[CH3:52])C>>[CH:30]1([N:36]([C@H:37]2[CH2:42][CH2:41][C@H:40]([CH2:43][O:44][CH2:45][CH3:46])[CH2:39][CH2:38]2)[C:17](=[O:18])[NH:60][C:58]2[S:59][C:55]([S:54][C:51]([CH3:53])([CH3:52])[C:50]([OH:49])=[O:61])=[CH:56][N:57]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

Participants

4

Reactant 3

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178467886HCID 178467886, compoundHCID 178495639HCID 178495639, compound

Product 1

HCID 178467890HCID 178467890, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(trans-4-ethoxymethyl-cyclohexyl)-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-5b578e5f3b9d4c0ea77768d6c47b316f
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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