Cyclohexyl-(4-phenyl-cyclohexyl)-amine → HCID 178525639, compound

HRID 731459Notes

Reaction equation

HRID 731459 reaction equation
C1(N([C@H]2CC[C@H](CC)CC2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16](O)=O)=[CH:12][N:13]=2)CCCC1.[CH:28]1([NH:34][CH:35]2[CH2:40][CH2:39][CH:38]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH2:37][CH2:36]2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.C([O:49][C:50](=[O:60])CCSC1SC(N)=NC=1)C>>[CH:28]1([N:34]([C@H:35]2[CH2:36][CH2:37][C@H:38]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH2:39][CH2:40]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][CH2:16][C:50]([OH:60])=[O:49])=[CH:12][N:13]=2)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1

Participants

4

Reactant 3

HCID 19381486Cyclohexyl-(4-phenyl-cyclohexyl)-amineHCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178455810HCID 178455810, compound

Product 1

HCID 178525639HCID 178525639, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(4-phenyl-cyclohexyl)-amine and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-406443d40b4a4e3d8b6e8e2296afd9d0
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

Loading…