N-(4-Phenylcyclohexyl)cycloheptanamine → 3-{2-[3-Cycloheptyl-3-(4-phenyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid

HRID 731461Notes

Reaction equation

HRID 731461 reaction equation
C1(N([C@H]2CC[C@H](CC)CC2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16](O)=O)=[CH:12][N:13]=2)CCCC1.[CH:28]1([NH:35][CH:36]2[CH2:41][CH2:40][CH:39]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:38][CH2:37]2)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.C([O:50][C:51](=[O:61])CCSC1SC(N)=NC=1)C>>[CH:28]1([N:35]([CH:36]2[CH2:41][CH2:40][CH:39]([C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)[CH2:38][CH2:37]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][CH2:16][C:51]([OH:61])=[O:50])=[CH:12][N:13]=2)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 29770255N-(4-Phenylcyclohexyl)cycloheptanamineHCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178455810HCID 178455810, compound

Product 1

HCID 576883543-{2-[3-Cycloheptyl-3-(4-phenyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cycloheptyl-(4-phenyl-cyclohexyl)-amine and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-e3a90983892149e8b530a88d56fdde23
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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