Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 178448126, compound

HRID 731468Notes

Reaction equation

HRID 731468 reaction equation
C1(N([C@H]2CC[C@H](CC)CC2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][N:13]=2)CCCC1.[CH:28]1([NH:35][C@H:36]2[CH2:41][CH2:40][C@H:39]([CH:42]([CH3:44])[CH3:43])[CH2:38][CH2:37]2)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH:28]1([N:35]([C@H:36]2[CH2:37][CH2:38][C@H:39]([CH:42]([CH3:44])[CH3:43])[CH2:40][CH2:41]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][N:13]=2)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178448111HCID 178448111, compoundHCID 178455810HCID 178455810, compound

Product 1

HCID 178448126HCID 178448126, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (Example 38) via cycloheptyl-(trans-4-isopropyl-cyclohexyl)-amine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-dc5907f493e046cda41446bc7fce0ec7
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

Loading…