Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 178455811, compound

HRID 731469Notes

Reaction equation

HRID 731469 reaction equation
[CH:1]1([N:6]([C@H:20]2[CH2:25][CH2:24][C@H:23]([CH2:26][CH3:27])[CH2:22][CH2:21]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][N:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:28]1(N[C@H]2CC[C@H](CC)CC2)CCCCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH:1]1([N:6]([C@H:20]2[CH2:21][CH2:22][C@H:23]([CH2:26][CH3:27])[CH2:24][CH2:25]2)[C:7](=[O:19])[NH:8][C:9]2[S:10][C:11]([S:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][N:13]=2)[CH2:2][CH2:3][CH2:4][CH2:28][CH2:5]1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178455797HCID 178455797, compoundHCID 178455810HCID 178455810, compound

Product 1

HCID 178455811HCID 178455811, compound

Procedure

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(trans-4-ethyl-cyclohexyl)-amine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-1378fb6d0dd54564844908e74ba500fa
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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