(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester → HCID 178525643, compound

HRID 731473Notes

Reaction equation

HRID 731473 reaction equation
C1(N([C@H]2CC[C@H](COC)CC2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17](O)=O)=[CH:13][N:14]=2)CCCCC1.[CH:30]1([NH:37][C@H:38]2[CH2:43][CH2:42][C@H:41]([CH2:44][O:45][CH2:46][CH:47]3[CH2:49][CH2:48]3)[CH2:40][CH2:39]2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C([O:52][C:53](=[O:63])C(SC1SC(N)=NC=1)C)C>>[CH:30]1([N:37]([C@H:38]2[CH2:43][CH2:42][C@H:41]([CH2:44][O:45][CH2:46][CH:47]3[CH2:49][CH2:48]3)[CH2:40][CH2:39]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][CH2:17][C:53]([OH:63])=[O:52])=[CH:13][N:14]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1

Participants

4

Reactant 3

HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178420364HCID 178420364, compoundHCID 178495639HCID 178495639, compound

Product 1

HCID 178525643HCID 178525643, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cycloheptyl-(trans-4-cyclopropylmethoxymethyl-cyclohexyl)-amine and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-d6b9ad3d4b1a49e7a4884dab8c5e5746
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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