N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycine → HCID 178458103, compound

HRID 731475Notes

Reaction equation

HRID 731475 reaction equation
C1(N(C2CCCCC2)C(=O)NC2SC(S(NC[C:20](O)=[O:21])(=O)=O)=CN=2)CCCCC1.[CH:30]1([NH:36][C@H:37]2[CH2:42][CH2:41][C@H:40]([CH3:43])[CH2:39][CH2:38]2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C[O:45][C:46](=[O:60])[C:47]([NH:50][S:51]([C:54]1[S:58][C:57]([NH2:59])=[N:56][CH:55]=1)(=[O:53])=[O:52])([CH3:49])[CH3:48]>>[CH:30]1([N:36]([C@H:37]2[CH2:38][CH2:39][C@H:40]([CH3:43])[CH2:41][CH2:42]2)[C:20](=[O:21])[NH:59][C:57]2[S:58][C:54]([S:51]([NH:50][C:47]([CH3:49])([CH3:48])[C:46]([OH:45])=[O:60])(=[O:53])=[O:52])=[CH:55][N:56]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

Participants

4

Reactant 3

HCID 57688273N-{2-[(Dicyclohexylcarbamoyl)amino]-1,3-thiazole-5-sulfonyl}glycineHCID 866301962-(2-Amino-thiazole-5-sulfonylamino)-2-methyl-propionic acid methyl esterHCID 178461295HCID 178461295, compound

Product 1

HCID 178458103HCID 178458103, compound

Procedure

Prepared in a similar manner to [2-(3,3-dicyclohexyl-ureido)-thiazole-5-sulfonylamino]-acetic acid via cyclohexyl-(trans-4-methyl-cyclohexyl)-amine and 2-(2-amino-thiazole-5-sulfonylamino)-2-methyl-propionic acid methyl ester to give the title compound.

Sources & evidence

ORD record
ord-6dc2c9ed1ca941f7a05ea43ce58e6fe3
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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