Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 178492590, compound

HRID 731482Notes

Reaction equation

HRID 731482 reaction equation
[CH:1]1([N:7]([C@H:21]2[CH2:26][CH2:25][C@H:24]([CH2:27]OC3C=CC=CC=3)[CH2:23][CH2:22]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(N[C@H]2CC[C@H]([CH2:49][O:50][C:51]3[CH:56]=[CH:55][C:54]([O:57][CH3:58])=[CH:53][CH:52]=3)CC2)CCCCCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH:21]1([N:7]([C@H:1]2[CH2:2][CH2:3][C@H:4]([CH2:49][O:50][C:51]3[CH:56]=[CH:55][C:54]([O:57][CH3:58])=[CH:53][CH:52]=3)[CH2:5][CH2:6]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:22][CH2:23][CH2:24][CH2:27][CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178492588HCID 178492588, compoundHCID 178526035HCID 178526035, compound

Product 1

HCID 178492590HCID 178492590, compound

Procedure

Prepared in a similar manner to {2-[3-cyclohexyl-3-(trans-4-phenoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cycloheptyl-[trans-4-(4-methoxy-phenoxymethyl)-cyclohexyl]-amine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester to give the title compound.

Sources & evidence

ORD record
ord-8706e6b82e794858922ee3cb95aa8cdd
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

Loading…